White Lyophilized Powder n acetyl selank peptide 5mg 10mg 2mg selank | Forum

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freemexy
freemexy Sep 19 '19
White Lyophilized Powder n acetyl selank peptide 5mg 10mg 2mg selank


Selank powder, which was developed in Russia, is a short peptide with nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper cells, monoamine neurotransmitters, and brain-derived neurotropic factor (BDNF). In fact, Selank and Tuftsin are essentially the same except that Selank has an additional four amino acids in its chain that help to improve metabolic stability and half-life.
Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.
Selank Anxiety Effects Based on Genes Related to GABA Neurotransmitter
According to Dr. Anastasiya Volkova of the Institute of Molecular Genetics in Russia, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. The clinical effects of Selank are similar to those of the classical antianxiety medications such as benzodiazepine, which are allosteric modulators of GABAA receptors and increase the inhibitory action of GABA.” Selank’s effects include reducing anxiety, improving mood, lower stress levels, and positively influencing memory and learning. Like benzodiazepines, low doses of Selank have a sedating effect. Unlike benzodiazepines, Selank does not appear to be habit-forming and does not lead to symptoms of withdrawal or amnesia.

Research in rats shows that of the 84 genes known to be connected to GABA signaling in some way, seven are heavily modulated by Selank and 45 show some change in expression when the peptide is administered. Overall, 52 genes related to GABA signaling are affected by Selank to some degree. These results indicate that Selank can directly influence the expression of genes in nerve cells and that it likely produces effects by changing the affinity of the GABA receptor for GABA[1].

This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.

When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.

Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.

Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.

When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.

Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.

Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].
lily
lily Jan 3
Mu in the gram Lin Gong inside, still keep gleaming weak light.Stalin Diao wears cigarette butt and take west the section Er Si radicle interview Peking and wave the soldier leave Anglo-French intelligence report, cloudy or sunny on the face uncertain.Say in the mind words, he from having never thoughting medium-frequency wave will make to arrive together, even if is all nation that he hates to the bone,have never thought them will walk to arrive together.What did Yang Qiu exactly allow a promise?The west section Er Si radicle exactly diagram what?Polack even if want again to reply a country, always can't think that China has been killed into Europe? A chain of problems that can not explain even diluted the joy that Finland surrenders, the shells benefit connecting to stand beside was second, the man of Mo Luo Tuo and just from come back of can the men are all equally wrinkly eyebrows.In their eyes, Yang Qiu for draw together an ally to deal with Su Wei Ai have been already gone crazy!Poland refugee government and exiled soldier the definite nobody care, the English method is only the meat shield that takes several ten thousand straggling soldiers bad generals as to block bullet, even the tanks didn't allot, it is thus clear that the English method doesn't value.But not value not representative not need, solidify the whole allieses then be scapegoat with the ally, is "virtue" of British Empire several a hundred years.The Qiu Ji Er can tolerate Su the Yi private's canal to the east temporarily lose, even can bite a tooth to ignore India first, but how will tolerate China to participate Mediterranean and Europe? "Do not give a Luo man comrade, what viewpoint do you have?"Stalin twists overdo, stare at eyes of Mo Luo Tuo's man.This is his habit, the confabulations will have eyes fixed on eyes of the other party each time, a lot of first times see of the persons are all consequently dejected even frightened. Even if so several years, not give Luo man still don't be used to a this kind of Duo Duo pressing look in the eyes, but don't dare to avert from again, have to speak remaining simply putting on the pipe of his corner of mouth his/her own viewpoint just:"Stalin comrade, Polack why do like this also to didn't news, but we have already received dependable intelligence report, fleet in Mediterranean, England has been already blocked up to fill harbor, hole rather Anne should be not want to put the Poland soldier of France a main force pass by.So I think and ignore them to have what scheme, Best Hunting Knife Yang Qiu all did the affair of piece birdbrain!
Maxxx
Maxxx May 24
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Maxxx
Maxxx Sep 28
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